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Atomic Force Microscopy

Pathogenic Neisseria meningitidis utilizes CD147 for vascular colonization.
Bernard, S. C. et al. Nat. Med. (2014). doi:10.1038/nm.3563

Flow Cytometry

Natural Killer Cells Induce Eosinophil Activation and Apoptosis. Ali Awad, Hanane Yassine, Mathieu Barrier, Han Vorng, Philippe Marquillies, Anne Tsicopoulos, Catherine Suez. PLOS One, 2014

RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage. Nugues AL, El Bouazzati H, Hétuin D, Berthon C, Loyens A, Bertrand E, Jouy N, Idziorek T, Quesnel B. Cell Death Dis. 2014 Aug 21 ;5:e1384

Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion. Deruy E, Nassour J, Martin N, Vercamer C, Malaquin N, Bertout J, Chelli F, Pourtier A, Pluquet O, Abbadie C. Cell Death Dis. 2014 Dec 18 ;5:e1577. doi : 10.1038/cddis.2014.533.

Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during Streptococcus pneumoniae infection. Van Maele L, Carnoy C, Cayet D, Ivanov S, Porte R, Deruy E, Chabalgoity JA, Renauld JC, Eberl G, Benecke AG, Trottein F, Faveeuw C, Sirard JC. J Infect Dis. 2014 Aug 1 ;210(3):493-503. doi : 10.1093/infdis/jiu106. Epub 2014 Feb 26.

High-Content Screening

Bhat R, Adam AT, Lee JJ, Deloison G, Rouille Y, Seron K, Rotella DP Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors Bioorg Med Chem Lett 24 4162-4165 2014

Marion E, Song OR, Christophe T, Babonneau J, Fenistein D, Eyer J, Letournel F, Henrion D, Clere N, Paille V, Guerineau NC, Saint Andre JP, Gersbach P, Altmann KH, Stinear TP, Comoglio Y, Sandoz G, Preisser L, Delneste Y, Yeramian E, Marsollier L, Brodin P Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways Cell 157 1565-1576 2014

Queval CJ, Song OR, Delorme V, Iantomasi R, Veyron-Churlet R, Deboosere N, Landry V, Baulard A, Brodin P A microscopic phenotypic assay for the quantification of intracellular mycobacteria adapted for high-throughput/high-content screening J Vis Exp e51114 2014

Rashed K, Sahuc, M.E., Deloison, G., Calland, N., Brodin, P., Rouillé, Y., Séron, K. Potent antiviral activity of Solanum rantonnetii and the isolated compounds against Hepatitis C Virus In-vitro. Journal of Functional Foods, 11, 185-191. 11 185-191 2014

Reboul A, Lemaitre N, Titecat M, Merchez M, Deloison G, Ricard I, Pradel E, Marceau M, Sebbane F Yersinia pestis requires the 2-component regulatory system OmpR-EnvZ to resist innate immunity during the early and late stages of plague J Infect Dis 210 1367-1375 2014

Villemagne B, Flipo M, Blondiaux N, Crauste C, Malaquin S, Leroux F, Piveteau C, Villeret V, Brodin P, Villoutreix BO, Sperandio O, Soror SH, Wohlkonig A, Wintjens R, Deprez B, Baulard AR, Willand N Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches J Med Chem 57 4876-4888 2014

Photonic Microscopy

Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles. Ligeon LA, Moreau K, Barois N, Bongiovanni A, Lacorre DA, Werkmeister E, Proux-Gillardeaux V, Galli T, Lafont F. Autophagy, 2014

miR126-5p repression of ALCAM and SetD5 in endothelial cells regulates leukocyte adhesion and transmigration. Loïc Poissonnier, Gaëlle Villain, Fabrice Soncin, Virginie Mattot. Cardiovascular Research, 2014

Nuclear glycolytic enzyme enolase of Toxoplasma gondii functions as a transcriptional regulator. Mouveaux T, Oria G, Werkmeister E, Slomianny C, Fox BA, Bzik DJ, Tomavo S. PLOS One, 2014

Application of a high power Yb fiber-based laser compatible with commercial optical parametric oscillator for coherent anti-Stokes Raman scattering microscopy. Hage CH, Boisset S, Ibrahim A, Morin F, Hoenninger C, Grunske T, Souissi S, Heliot L, Leray A. Microsc Res Tech. 2014 Jun ;77(6):422-30.

PRC1 components exhibit different binding kinetics in Polycomb bodies. Vandenbunder B, Fourré N, Leray A, Mueller F, Völkel P, Angrand PO, Héliot L. Biol Cell. 2014 Apr ;106(4):111-25

Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis. Malaquin N, Vercamer C, Bouali F, Martien S, Deruy E, Wernert N, Chwastyniak M, Pinet F, Abbadie C, Pourtier A. PLoS One. 2013 May 10 ;8(5):e63607. doi : 10.1371/journal.pone.0063607. Print 2013.

Implementation of transportation distance for analyzing FLIM and FRET experiments. Heinrich P, Gonzalez Pisfil M, Kahn J, Héliot L, Leray A. Bull Math Biol. 2014 Oct ;76(10):2596-626.

Electron Microscopy

Autophagy in osteoblasts is involved in mineralization and bone homeostasis. Nollet M, Santucci-Darmanin S, Breuil V, Al-Sahlanee R, Cros C, Topi M, Momier D, Samson M, Pagnotta S, Cailleteau L, Battaglia S, Farlay D, Dacquin R, Barois N, Jurdic P, Boivin G, Heymann D, Lafont F, Lu SS, Dempster DW, Carle GF, Pierrefite-Carle V. Autophagy. 2014 ;10(11):1965-77. doi : 10.4161/auto.36182.

A functional fragment of Tau forms fibers without the need for an intermolecular cysteine bridge. Huvent I, Kamah A, Cantrelle FX, Barois N, Slomianny C, Smet-Nocca C, Landrieu I, Lippens G. Biochem Biophys Res Commun. 2014 Mar 7 ;445(2):299-303. doi : 10.1016/j.bbrc.2014.01.161. Epub 2014 Feb 3.

Tungsten carbide-cobalt as a nanoparticulate reference positive control in in vitro genotoxicity assays. Moche H, Chevalier D, Barois N, Lorge E, Claude N, Nesslany F. Toxicol Sci. 2014 Jan ;137(1):125-34. doi : 10.1093/toxsci/kft222. Epub 2013 Oct 1.