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Accueil > R&D > Publications

2017

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Photonic m.

Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins.
Jia J, Werkmeister E, Gonzalez-Hilarion S, Leroy C, Gruenert DC, Lafont F, Tulasne D, Lejeune F.
J Cell Sci. 2017 Sep 15 ;130(18):3009-3022. doi : 10.1242/jcs.198176.

Phenotypic assays for Mycobacterium tuberculosis infection.
Song OR, Deboosere N, Delorme V, Queval CJ, Deloison G, Werkmeister E, Lafont F, Baulard A, Iantomasi R, Brodin P.
Cytometry A. 2017 Oct ;91(10):983-994.

CLAFEM : Correlative light atomic force electron microscopy.
Janel S, Werkmeister E, Bongiovanni A, Lafont F, Barois N.
Methods Cell Biol. 2017 ;140:165-185. doi : 10.1016/bs.mcb.2017.03.010.

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division.
Venugopal K, Werkmeister E, Barois N, Saliou JM, Poncet A, Huot L, Sindikubwabo F, Hakimi MA, Langsley G, Lafont F, Marion S.
PLoS Pathog. 2017 Apr 21 ;13(4):e1006331. doi : 10.1371/journal.ppat.1006331. eCollection 2017 Apr.

Characterization of a nuclear pore protein sheds light on the roles and composition of the Toxoplasma gondii nuclear pore complex.
Courjol F, Mouveaux T, Lesage K, Saliou JM, Werkmeister E, Bonabaud M, Rohmer M, Slomianny C, Lafont F, Gissot M.
Cell Mol Life Sci. 2017 Jun ;74(11):2107-2125. doi : 10.1007/s00018-017-2459-3.

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.
Malmanche N, Dourlen P, Gistelinck M, Demiautte F, Link N, Dupont C, Vanden Broeck L, Werkmeister E, Amouyel P, Bongiovanni A, Bauderlique H, Moechars D, Royou A, Bellen HJ, Lafont F, Callaerts P, Lambert JC, Dermaut B.
Sci Rep. 2017 Jan 23 ;7:40764. doi : 10.1038/srep40764.

MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering.
Montagne R, Baranzelli A, Muharram G, Catherine L, Lesaffre M, Vinchent A, Kherrouche Z, Werkmeister E, Cortot AB, Tulasne D.
Oncotarget. 2017 Feb 14 ;8(7):11268-11283. doi : 10.18632/oncotarget.14499.

Imaging and cell count in cleared intact cochlea in the Mongolian gerbil using laser scanning confocal microscopy.
Risoud M, Sircoglou J, Dedieu G, Tardivel M, Vincent C, Bonne NX.
Eur Ann Otorhinolaryngol Head Neck Dis. 2017 Sep ;134(4):221-224.

Defining the human sperm microtubulome : an integrated genomics approach.
Jumeau F, Chalmel F, Fernandez-Gomez FJ, Carpentier C, Obriot H, Tardivel M, Caillet-Boudin ML, Rigot JM, Rives N, Buée L, Sergeant N, Mitchell V.
Biol Reprod. 2017 Jan 1 ;96(1):93-106.

AFM

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation.
Stefani C, Gonzalez-Rodriguez D, Senju Y, Doye A, Efimova N, Janel S, Lipuma J, Tsai MC, Hamaoui D, Maddugoda MP, Cochet-Escartin O, Prévost C, Lafont F, Svitkina T, Lappalainen P, Bassereau P, Lemichez E.
Nat Commun. 2017 Jun 23 ;8:15839.

Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4.
Maïssa N, Covarelli V, Janel S, Durel B, Simpson N, Bernard SC, Pardo-Lopez L, Bouzinba-Ségard H, Faure C, Scott MGH, Coureuil M, Morand PC, Lafont F, Nassif X, Marullo S, Bourdoulous S. Nat Commun. 2017 Jun 1 ;8:15764.

CLAFEM : Correlative light atomic force electron microscopy.
Janel S, Werkmeister E, Bongiovanni A, Lafont F, Barois N.
Methods Cell Biol. 2017 ;140:165-185.

Adhesiveness of opportunistic Staphylococcus aureus to materials used in dental office : In vitro study.
Merghni A, Bekir K, Kadmi Y, Dallel I, Janel S, Bovio S, Barois N, Lafont F, Mastouri M. 
Microb Pathog. 2017 Feb ;103:129-134.

Standardized Nanomechanical Atomic Force Microscopy Procedure (SNAP) for Measuring Soft and Biological Samples.
Schillers H, Rianna C, Schäpe J, Luque T, Doschke H, Wälte M, Uriarte JJ, Campillo N, Michanetzis GPA, Bobrowska J, Dumitru A, Herruzo ET, Bovio S, Parot P, Galluzzi M, Podestà A, Puricelli L, Scheuring S, Missirlis Y, Garcia R, Odorico M, Teulon JM, Lafont F, Lekka M, Rico F, Rigato A, Pellequer JL, Oberleithner H, Navajas D, Radmacher M.
Sci Rep. 2017 Jul 11 ;7(1):5117.

Role of Hydrophobins in Aspergillus fumigatus.
Valsecchi I, Dupres V, Stephen-Victor E, Guijarro JI, Gibbons J, Beau R, Bayry J, Coppee JY, Lafont F, Latgé JP, Beauvais A.
J Fungi (Basel). 2017 Dec 24 ;4(1).

Cytometry

Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections.
Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C.
Mucosal Immunol. 2017 Jul ;10(4):1056-1068.

Type I IFN Receptor Signaling Controls IL7-Dependent Accumulation and Activity of Protumoral IL17A-Producing γδT Cells in Breast Cancer.
Patin EC, Soulard D, Fleury S, Hassane M, Dombrowicz D, Faveeuw C, Trottein F, Paget C.
Cancer Res. 2018 Jan 1 ;78(1):195-204.

Role of IRF4 in resistance to immunomodulatory (IMid) compounds® in Waldenström’s macroglobulinemia.
Bertrand E, Jouy N, Manier S, Fouquet G, Guidez S, Boyle E, Noel S, Tomowiak C, Herbaux C, Schraen S, Preudhomme C, Quesnel B, Poulain S, Leleu X.
Oncotarget. 2017 Dec 4 ;8(68):112917-112927.

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Laurent C, Dorothée G, Hunot S, Martin E, Monnet Y, Duchamp M, Dong Y, Légeron FP, Leboucher A, Burnouf S, Faivre E, Carvalho K, Caillierez R, Zommer N, Demeyer D, Jouy N, Sazdovitch V, Schraen-Maschke S, Delarasse C, Buée L, Blum D.
Brain. 2017 Jan ;140(1):184-200.

Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.
Malmanche N, Dourlen P, Gistelinck M, Demiautte F, Link N, Dupont C, Vanden Broeck L, Werkmeister E, Amouyel P, Bongiovanni A, Bauderlique H, Moechars D, Royou A, Bellen HJ, Lafont F, Callaerts P, Lambert JC, Dermaut B.
Sci Rep. 2017 Jan 23 ;7:40764

Electron m.

Short-term exposure to gold nanoparticle suspension impairs swimming behavior in a widespread calanoid copepod.
Michalec FG, Holzner M, Barras A, Lacoste AS, Brunet L, Lee JS, Slomianny C, Boukherroub R, Souissi S.
Environ Pollut. 2017 Sep ;228:102-110.

Adhesiveness of opportunistic Staphylococcus aureus to materials used in dental office : In vitro study.
Merghni A, Bekir K, Kadmi Y, Dallel I, Janel S, Bovio S, Barois N, Lafont F, Mastouri M.
Microb Pathog. 2017 Feb ;103:129-134

Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division.
Venugopal K, Werkmeister E, Barois N, Saliou JM, Poncet A, Huot L, Sindikubwabo F, Hakimi MA, Langsley G, Lafont F, Marion S.
PLoS Pathog. 2017 Apr 21 ;13(4):e1006331.

CLAFEM : Correlative light atomic force electron microscopy.
Janel S, Werkmeister E, Bongiovanni A, Lafont F, Barois N.
Methods Cell Biol. 2017 ;140:165-185

HCS

Host-pathogen systems for early drug discovery against tuberculosis.
Trofimov V, Costa-Gouveia J, Hoffmann E, Brodin P.
Curr Opin Microbiol. 2017 Oct ;39:143-151.

Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids.
Blanc L, Gilleron M, Prandi J, Song OR, Jang MS, Gicquel B, Drocourt D, Neyrolles O, Brodin P, Tiraby G, Vercellone A, Nigou J.
Proc Natl Acad Sci U S A. 2017 Oct 17 ;114(42):11205-11210.

Mycobacterium tuberculosis Controls Phagosomal Acidification by Targeting CISH-Mediated Signaling.
Queval CJ, Song OR, Carralot JP, Saliou JM, Bongiovanni A, Deloison G, Deboosère N, Jouny S, Iantomasi R, Delorme V, Debrie AS, Park SJ, Gouveia JC, Tomavo S, Brosch R, Yoshimura A, Yeramian E, Brodin P.
Cell Rep. 2017 Sep 26 ;20(13):3188-3198.

Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.
Nguyen PC, Delorme V, Bénarouche A, Martin BP, Paudel R, Gnawali GR, Madani A, Puppo R, Landry V, Kremer L, Brodin P, Spilling CD, Cavalier JF, Canaan S.
Sci Rep. 2017 Sep 18 ;7(1):11751.

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages.
Escoll P, Song OR, Viana F, Steiner B, Lagache T, Olivo-Marin JC, Impens F, Brodin P, Hilbi H, Buchrieser C.
Cell Host Microbe. 2017 Sep 13 ;22(3):302-316.e7.

A Bacterial Toxin with Analgesic Properties : Hyperpolarization of DRG Neurons by Mycolactone.
Song OR, Kim HB, Jouny S, Ricard I, Vandeputte A, Deboosere N, Marion E, Queval CJ, Lesport P, Bourinet E, Henrion D, Oh SB, Lebon G, Sandoz G, Yeramian E, Marsollier L, Brodin P.
Toxins (Basel). 2017 Jul 18 ;9(7). pii : E227.

Combination therapy for tuberculosis treatment : pulmonary administration of ethionamide and booster co-loaded nanoparticles.
Costa-Gouveia J, Pancani E, Jouny S, Machelart A, Delorme V, Salzano G, Iantomasi R, Piveteau C, Queval CJ, Song OR, Flipo M, Deprez B, Saint-André JP, Hureaux J, Majlessi L, Willand N, Baulard A, Brodin P, Gref R.
Sci Rep. 2017 Jul 14 ;7(1):5390.

Phenotypic assays for Mycobacterium tuberculosis infection.
Song OR, Deboosere N, Delorme V, Queval CJ, Deloison G, Werkmeister E, Lafont F, Baulard A, Iantomasi R, Brodin P.
Cytometry A. 2017 Oct ;91(10):983-994.

Host-directed therapies offer novel opportunities for the fight against tuberculosis.
Machelart A, Song OR, Hoffmann E, Brodin P.
Drug Discov Today. 2017 Aug ;22(8):1250-1257.

Cyclodextrin-based nanocarriers containing a synergic drug combination : A potential formulation for pulmonary administration of antitubercular drugs.
Salzano G, Wankar J, Ottani S, Villemagne B, Baulard AR, Willand N, Brodin P, Manet I, Gref R.
Int J Pharm. 2017 Oct 15 ;531(2):577-587.

Impact of pe_pgrs33 Gene Polymorphisms on Mycobacterium tuberculosis Infection and Pathogenesis.
Camassa S, Palucci I, Iantomasi R, Cubeddu T, Minerva M, De Maio F, Jouny S, Petruccioli E, Goletti D, Ria F, Sali M, Sanguinetti M, Manganelli R, Rocca S, Brodin P, Delogu G.
Front Cell Infect Microbiol. 2017 Apr 21 ;7:137.

Clofazimine encapsulation in nanoporous silica particles for the oral treatment of antibiotic-resistant Mycobacterium tuberculosis infections.
Valetti S, Xia X, Costa-Gouveia J, Brodin P, Bernet-Camard MF, Andersson M, Feiler A.
Nanomedicine (Lond). 2017 Apr ;12(8):831-844

Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
Nikiforov PO, Blaszczyk M, Surade S, Boshoff HI, Sajid A, Delorme V, Deboosere N, Brodin P, Baulard AR, Barry CE 3rd, Blundell TL, Abell C.
ACS Chem Biol. 2017 May 19 ;12(5):1390-1396.

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
Blondiaux N, Moune M, Desroses M, Frita R, Flipo M, Mathys V, Soetaert K, Kiass M, Delorme V, Djaout K, Trebosc V, Kemmer C, Wintjens R, Wohlkönig A, Antoine R, Huot L, Hot D, Coscolla M, Feldmann J, Gagneux S, Locht C, Brodin P, Gitzinger M, Déprez B, Willand N, Baulard AR.
Science. 2017 Mar 17 ;355(6330):1206-1211.

How can nanoparticles contribute to antituberculosis therapy ?
Costa-Gouveia J, Aínsa JA, Brodin P, Lucía A.
Drug Discov Today. 2017 Mar ;22(3):600-607.

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism.
Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JSK, Leroux F, Herledan A, Demiautte F, Bauer C, Checler F, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Albert M, Moghekar A, O’Brien R, Peskind ER, Malmanche N, Schellenberg GD, Dourlen P, Song OR, Cruchaga C, Amouyel P, Deprez B, Brodin P, Lambert JC ; ADGC, Alzheimer’s Disease Neuroimaging Initiative.
Acta Neuropathol. 2017 Jun ;133(6):955-966.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.
Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.
Mol Microbiol. 2017 Jan ;103(1):13-25.

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis.
Deboosère N, Iantomasi R, Queval CJ, Song OR, Deloison G, Jouny S, Debrie AS, Chamaillard M, Nigou J, Cohen-Gonsaud M, Locht C, Brodin P, Veyron-Churlet R.
Cell Microbiol. 2017 Jan ;19(1). doi : 10.1111/cmi.12619

New active leads for tuberculosis booster drugs by structure-based drug discovery.
Tatum NJ, Liebeschuetz JW, Cole JC, Frita R, Herledan A, Baulard AR, Willand N, Pohl E.
Org Biomol Chem. 2017 Dec 13 ;15(48):10245-10255.

Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.
Wohlkönig A, Remaut H, Moune M, Tanina A, Meyer F, Desroses M, Steyaert J, Willand N, Baulard AR, Wintjens R.
Biochem Biophys Res Commun. 2017 May 27 ;487(2):403-408.